Cosby and Monacan, the top two girls seeds from the Dominion District, advanced to the Central Region quarterfinals with convincing wins.
The Titans (20-6) took down J.R. Tucker 62-38 as Jazmin Pitts registered 23 points and grabbed 14 rebounds to lead the way. Becca Wann added 18 and Andrea Bertrand 11 for Cosby, who advances to face Thomas Dale Wednesday.
Cosby trailed by five points at halftime as Kerry Johnson (10 points) and Katie Huband (10) were playing well for the Tigers, but Cosby pulled away with a 19-7 third period.
The Chiefs, the Dominion District tournament champs, pounded Hermitage 79-42 to advance to face Meadowbrook.
Candice Silas (16 points), Rachel Robinson (14), Jordan Beadles (12) and Victoya Ricks (10) reached double digits for the Chiefs.
Brianna Dillard had a sensational night for Hermitage with 25 points.